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Some vaccines may leave the area sore for a day or two
The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency

People who may be at a higher risk for B12 deficiency include older adults, those with gastrointestinal disorders, vegetarians and vegans, and those who have had gastrointestinal surgery

doi: 10.1016/s0149-2918(03)90096-8