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After CR in rats, a reduction in the degeneration of GABAergic neurons in the hippocampus and the entorhinal cortex was shown before the administration of kainic acid ( Physiological Effects of Caloric Restriction on Wnt /B-Catenin on the Brain New signaling pathways have been postulated on the effects of caloric restriction in the brain, one of them involving glycolytic metabolism in neurons, but little is known about the intervention of the Wnt /-catenin pathway ( The stimulation of cortical neurons with Wnt 3a stimulates glucose absorption without significant changes in the expression and the functionality of glucose transporter 3 (GLUT3), but with an increase in its affinity

The activity of sirtuins is linked to longevity