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In studies with mouse models of NAFLD and acute kidney injury (AKI), treatment with ACMSD inhibitors increased the transcription of mitochondrial and -oxidation genes, as well as restoring NAD + levels in the kidney and liver 235

Acta 1866:165878

In contrast, the triazole-based compound IIIM(S)-RS98 induces apoptosis in lung cancer cells via mitochondrial and PI3K/Akt pathways ( Figure 4 )
