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A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis

Given the scoping nature of the review and the heterogeneity of available evidence, study selection focused on identifying representative and clinically informative literature rather than exhaustive quantitative inclusion

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Food and Drug Administration (FDA) approved low-dose colchicine to help prevent cardiovascular events in people with known atherosclerosis (specifically, those who have already experienced a heart attack or stroke, or have clinical signs of coronary artery disease) or multiple cardiovascular risk factors