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Their presence is closely connected to alcohol consumption, and the wellknown CDT as well as sialic acid and EtG are the result of alcoholinduced glycoconjugate metabolites.30 The highest sensitivity of up to 99% was observed for Peth 31, 41 that showed a rapid decrease at the beginning of withdrawal, a slow decline after the first few days, and persistence at low levels beyond 19d of abstinence.42 Apart from biomarkers detected in blood and urine samples, saliva is a promising and easy accessible material to detect glycomarkers of oxidative stress,43, 44 but the reproducibility and validity in Peth has to be proven for clinical routine application.45 As an antibody based flash test is available for detection of EtG in urine with good sensitivity and specificity, this parameter is the most promising one to be integrated in routine laboratory settings and in screening of patients at risk to develop AWS.46 As long as ethanol is metabolized, the metabolism of serotonin is shifted from formation of 5hydroxyindole3acetic acid (5HIAA) toward 5hydroxytryptophol (5HTOL)

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