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Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications
[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Rose S., Melnyk S., Pavliv O., Bai S., Nick T.G., Frye R.E., James S.J
The mechanism suggests: impaired MTHFR reduced methylfolate reduced methionine recycling reduced SAMe production reduced COMT activity slower clearance of catechol estrogen metabolites accumulation of active estrogen metabolites estrogen dominance symptoms [2, 7]

Hannon, C