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Jin-Ao Duan, [email protected] These authors have contributed equally to this work This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Further, different doses of ascorbate and different dosing regimens used within these experiments rarely reflected a clear pattern of results or obvious dose-response relationships