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Hepatology 2009;50:2014-2021

22,56,57 Cardiovascular diseases and related risk factors (e.g., hypertension, atherosclerosis) impair blood flow to peripheral nerves, worsening neuropathic symptoms
Its broad binding across the melanocortin receptors is why researchers have used it to probe systems from pigmentation biology to energy balance and central arousal

4e and Supplementary Fig