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C-Met expression is controlled by the -catenin signaling and downregulated by inhibition of Wnt signaling using Frzb and DNLRP5, two Wnt antagonists [103, 104]
Additionally, prolyl hydroxylase domain (PHD) inhibitors, such as the clinical drug Roxadustat (FG-4592), are capable of treating a variety of recalcitrant anaemiaincluding refractory anaemia, inflammatory anaemias, and chemotherapy-associated anaemiasby activating the HIF-2 axis [100]
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[DOI] [PubMed] [Google Scholar] Kaur IP, Garg A, Singla AK, Aggarwal D
