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An assessment was carried out on models of pancreatic intraepithelial neoplasia (PanIN) and PDAC in rats to investigate the differences in their metabonomics and to explore the molecular mechanisms that contribute to these variations

doi: 10.1016/j.jinorgbio.2007.06.003
The surface receptors on cancer cells engage with ECM components and ECM-bound factors, facilitating cell adhesion and signaling, which in turn regulate a wide array of processes such as proliferation, differentiation, migration (Gonzalez and Medici, 2014)
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