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Description
Their organization into broad categories represents an interconnected hierarchy where the primary hallmarks reflect macromolecular damage (i.e., genome, proteome, organelles) which lead to antagonistic hallmarks, e.g., response to the damage
Most RNA viruses replicate with estimated error rates between 10 3 and 10 5 , which results in approximately one mutation per genome per round of replication for a typical 10-kb genome 134 , a much higher mutation rate than occurs in cellular DNA replication 135
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2022;355 doi: 10.1016/j.cbi.2022.109804
