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Figure 8 6.4 Heart diseases and polyphenols Globally, cardiovascular diseases are the leading cause of mortality, according to data from the World Health Organization (WHO)
However, -syn-induced astrocytic mitochondrial dysfunction disrupts this detoxification pathway, leading to toxic lipid reaccumulation in neurons and establishing a PD-accelerating feedback loop (166,167)

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
