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4.5 Intranasal administration Drugs delivered to the olfactory region via IN can reach the olfactory bulb and other CNS regions within minutes via intracellular and extracellular pathways along the olfactory nerves or diffusion (especially for lipophilic small molecules), allowing for a higher concentration of the therapeutic agents in the brain compared to the bloodstream

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First, many nanozymes exhibit oxidoreductase-like activities due to their exceptional electron transfer capacity 61,62 , yet redox reactions are inherently challenging to control