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the cells were cultured in DMEM (GibcoBRL, Rockville, MD, USA) with 10% foetal bovine serum (04-001-1A, Biological Industries) and incubated at 37 C and 5% carbon dioxide

Many OXPHOS inhibitors or SHMT2 inhibitors exhibit narrow therapeutic windows and significant side effects [187]

the supernatant was used for RNA extraction
