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Plasma cell differentiation is accompanied by endoplasmic reticulum enlargement, increased membrane-bound ribosomes, upregulation of endoplasmic reticulum chaperones such as BIP and GRP94, and transcription factors like XBP-1 (106)

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Furthermore, single nucleotide polymorphisms in OCTN2 are associated with increased susceptibility to Crohns inflammatory bowel disease 10

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