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SMART: recent updates, new developments and status in 2020

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Contents Introduction Components of insulin-like growth factor (IGF) signaling axis IGF system and hepatocellular carcinoma Tissue expression of IGF axis components in HCC Role of IGF axis in HCV-related hepatocellular carcinoma IGF axis components and HCV genome Conclusions Introduction In HCV-related hepatocarcinogenesis, participation of viral proteins: core (C), non-structural 3 (NS3) and NS5 proteins themselves used to be accentuated (13)

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