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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
-dicarbonyl compounds are important intermediates in glycation reactions, which are highly reactive and can rapidly bind to proteins to form AGEs
Sukumar S, Mukherjee MB, Colah RB, Mohanty D, 2004
Activated neutrophils release a potent arsenal of damaging agents, including ROS, various proteases (notably neutrophil elastase), and myeloperoxidase (MPO) (Pinzaru et al., 2023)
