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We hypothesized that the emergence of metabolic syndrome in individuals with schizophrenia occurs even before the initiation of antipsychotic treatment, potentially due to oxidative stress abnormalities, which may in turn be influenced by polymorphisms in the glutathione-regulating gene GCLC

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However, while zebrafish provide substantial advantages, such as transparency of embryos and larvae, ease of drug administration, and rapid development, this model also has limitations in fully replicating the complexity of the human TME (Shimizu et al