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Any over-activity or inhibition of these systems may lead to lesions in different organs

CNS target engagement will be assessed by measuring levels of key senescence markers in CSF at baseline and after three months treatment with senolytics

The current review emphasises the importance of the gut barrier in limiting the systemic entry of luminal contents and highlights how strategies to improve its integrity represent a useful approach in reducing the prevalence and burden of gut-associated and extraintestinal inflammatory diseases

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