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While it is possible that some of these differences may be associated with subtype-specific signaling (D5 is anti-inflammatory and D1 is proinflammatory), this seems unlikely, as both D1 (Yan et al., 2015) and D5 (Wu et al., 2020

Symptoms include chronic headache, blurred vision, tingling sensations, nausea, and vomiting

Although it is rare, too much niacin from supplements could cause red skin, tingling in the face, arms and chest, and itching
