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Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA
[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Moreira B.P., Silva A.M., Martins A.D., Monteiro M.P., Sousa M., Oliveira P.F., Alves M.G
Funding acquisition, L.L.H
Orally induced high serum level of trimethylamine N-oxide worsened glial reaction and neuroinflammation on MPTP-induced acute Parkinsons disease model mice
