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Neutrophils are thought to promote cuprizone demyelination as knocking out the neutrophil chemokine receptor, CXCR2, in mice prevents demyelination at week 6 of cuprizone treatment

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The goal is progressive loading that stimulates further tissue adaptation without exceeding the healing tissues capacity
Topical steroids, vitamin D analogs, phototherapy, and IL-17/IL-23 biologics have strong evidence that peptides cannot match