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Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China ORCID: Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China Affiliation: Department of Neurology, Shandong University Qilu Hospital, Jinan 250012, Shandong, China Email: [email protected] ORCID: Explor Neuroprot Ther

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However, this perception began to shift in 1921 when Otto Warburg demonstrated that tumor cells preferentially metabolize glucose into lactate via aerobic glycolysis, underscoring its pivotal role in tumor metabolism [5]