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eLife 9:e54441

These effects were partially or, in some cases, even completely abolished in the presence of the eNOS inhibitor N()-nitro-L-arginine methyl ester (L-NAME), suggesting a potential role for this enzyme in the pharmacological properties of NaHS

doi: 10.3389/fphys.2025.1606528 Received 05 April 2025 Revised 29 August 2025 Accepted 03 September 2025 Published 24 November 2025 Volume 16 - 2025 Edited by Dario C

The occurrence of a single subject with evidence of overt hemolysis associated with an amustaline/GSH antibody would require a clinical hold with evaluation and DSMB and FDA approval to continue enrolment