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Hence, increased DA signaling might contribute to mPFC hyperexcitability as reported here and previously reported hyperactive DA neurons in the ventral tegmental area [4, 5]

Danielsson J, Kangastupa P, Laatikainen T, Aalto M, Niemel O

While tirzepatide demonstrates slightly greater weight loss efficacy, its side effect profile is similar to semaglutide, with gastrointestinal symptoms being most common

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