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Description
Excess tumor-derived lactate leads to lactic acid accumulation, which impairs CD8 + T cell effector functions through intracellular acidification and inhibition of glycolytic enzymes such as GAPDH
There are no stupid questions, but there are a LOT of inquisitive idiots
glutamic acid, cysteine, and glycine The synthesis of glutathione in the body involves two enzymes, the first of which binds L-cysteine and glutamic acid to one another in a gamma configuration (producing -glutamylcysteine), and the second enzyme adds a glycine molecule onto it to ultimately form glutathione
Kligerman A
