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Liu Y, Keyomarsi K, Lu X, Swisher SG , Hunt KK

The cellular response to exogenous H 2 S released by the donors has been considered as a biphasic response, in which low H 2 S concentrations (or low H 2 S production rates) showed enhancement of cell proliferation rates and cell viability whereas high H 2 S caused deleterious/adverse effects in cells [50, 65]

Moreover, apoptosis and cell death were reversed by downregulation of all apoptotic key markers reflected with decreased serum levels of ALP and AST toward their corresponding normal values, as well as histological signs of liver cell membrane stabilization and repair of hepatic tissue damage

Data analysis was performed using FlowJo v10.9 (BD Biosciences)