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Healthcare professionals should maintain a low threshold for B12 testing in symptomatic patients, particularly those with risk factors, and should not delay treatment when neurological involvement is suspected

Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, et al

This process is facilitated by the protonation of amine groups grafted onto the polymer surface within endosomes (pH 56) and lysosomes (pH 45), which possess strong proton-buffering capacity and induce rapid osmotic swelling, thereby promoting cargo release

One of these compounds is lipopolysaccharide, as a component of gram-negative bacteria with pro-inflammatory effects