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In summary, astrocytes orchestrate neuronal death in PD through diverse mechanisms, offering novel therapeutic targets for intervention

Glutathione acts as the ligand and the complementary GST tag acts both as a purification anchoring point and as a solubility/stability enhancer, which justifies the popularity of this affinity pair system (Frangioni and Neel, 1993, Smith, 2000)

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This hypothesis can further guide biophysical and biochemical experiments on the execution mechanism of ferroptosis in the future
