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More extremely, when NAM is at an acute pharmacological dose, it is mainly converted to NAM N-oxide by CYP2E1 (Km = 2.98 mM) as quickly as possible [810]

Local injection near the injury site delivers high peptide concentrations directly to affected tissues

Lumbar plexopathies: These conditions can cause sensory and motor deficits without any pain, depending on the cause
