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System Xc (a special cystine/glutamate transporter) exchanges intracellular glutamate for extracellular cystine in a 1:1 ratio (Dixon et al., 2012), driven by the high intracellular glutamate concentration rather than adenosine triphosphate (Bridges et al., 2012

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Still in late-stage trials (Phase 3)

After heavy metal was removed, the memory of expression developed, and heavy metal-transporting P-type ATPase genes (HMAs) were activated due to heavy metal-associated stress ( Figure 2 illustrates the epigenetic regulation of stress-responsive genes across abiotic stresses