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Three main hypotheses were proposed to explain how riboflavin deficiency can lead to low parasitaemia: haemolysis, inhibition of reticulocytosis, and oxidative stress
Nature 567 , 118122 (2019)
There might be a slight bit of discomfort, more from the surprise of the flash of light than actual pain or discomfort
They are classed as extremophiles as they can survive dry conditions by changing into a desiccated state, in which they can remain for many years
