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Gene set enrichment analysis (GSEA) was performed with 1000 permutations to identify enriched biological functions and activated pathways from the molecular signatures database (MSigDB), which included hallmark gene sets, positional gene sets, curated gene sets, motif gene sets, computational gene sets, GO gene sets, oncogenic gene sets, and immunologic gene sets

In other cell types such as spermatogonial cells, GSH depletion may induce autophagy 22

doi: 10.3748/wjg.v17.i12.1519 239 ZelanteTIannittiRGCunhaCDe LucaAGiovanniniGPieracciniGet al

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: Outsourcing a key task