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Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

Ferroptosis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma
Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones
