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Estrogen is proposed to exert its effects through activation of the MAP kinase pathway and transcription factor NF-B, leading to increased expression of antioxidant enzymes such as superoxide dismutase (Farhat et al., 2017

3 A widely used non-radioactive alternative is the C breath test , in which a stable-isotope-labeled substrate (often octanoate or spirulina) is metabolized after it passes into the small intestine, so the rate of labeled CO appearance in the breath reports on emptying

Baseline measurements before starting, periodic monitoring during use, and follow-up assessment after cycling off provide data points that can reveal individual response patterns

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