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Furthermore, resveratrol has been observed to prevent the expression of class I, II, and IV HDACs in liver cancer cells (HepG2, Hep3B, and HuH7 cells), further inhibiting cancer cell growth and proliferation (Gao and Tollefsbol 2015

While primarily studied in research settings, CJC-1295 has shown potential therapeutic applications, though its clinical use is not widespread

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These findings collectively establish a multilevel regulatory mechanism through which the nanoengineered system achieves superior therapeutic efficacy in maintaining mitochondrial ER homeostasis and counteracting chemotherapy-induced cardiac dysfunction