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As for PDPN targeting, the relief of the inhibitory signal delivered through the CD47-SIRP- binding on macrophages could generate a pro-inflammatory TME favoring the anti-MB immune response, as indicated for other tumor types (287, 288)

Statistical analysis All experimental data were obtained from at least three independent experiments

268 The proof of the conjecture with mushroom proteins came quite recently with the characterization of a heme dioxygenase in Coprinopsis cinerea

Consequently, the IL-23/Th17 axis has emerged as one of the premier therapeutic targets (e.g., IL-23p19 inhibitors) (Samarani et al., 2020)