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Vitamin B-12 deficiency symptoms include depression and mood disorders, fatigue, memory failure, anemia, low blood pressure, and high homocysteine levels

Patients consuming significantly fewer calories may not meet requirements for essential micronutrients, including B vitamins, iron, and vitamin D, all of which play crucial roles in energy metabolism

Cell 98(2):193205 Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM (2000) Interacting molecular loops in the mammalian circadian clock

Acknowledgments We thank Universidad del Rosario for the administrative support with this publication