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The identification of neuroprotective agents for PD provides us with therapeutic opportunities for modifying the course of disease progression and, perhaps, reducing the risk of onset when preclinical biomarkers become available
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PPAR, PPAR/ and PPAR are the three identified isoforms of PPARs
The authors hypothesized that H 2 O 2 formation in the mitochondria results in the inactivation of ATG4, promoting ATG8 lipidation, and thus, activation of autophagy
