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Yoshida H, Arai S, Hara KY, Yamada R, Ogino C, Fukuda H, Kondo A (2011) Efficient and direct glutathione production from raw starch using engineered Saccharomyces cerevisiae

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

However, these beneficial effects are counterbalanced by concerns that probiotics could act as vectors for harmful co-contaminants such as heavy metals or persistent organic pollutants [36],[63]
This fundamental difference implies that natural compounds might require less frequent dosing to achieve a continuous neuroprotective effect, whereas levodopa's dosing frequency is strictly determined by its short pharmacokinetics [101]
