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Studies have shown that serum miR-223 levels are elevated in patients with AH, and miR-223 deficiency exacerbates ethanol-induced inflammation, oxidative stress, and liver damage [82]

Decentralized Clinical Trials Market Share The global DCT market exhibits moderate concentration at the top tier and a highly fragmented long tail of technology-native and specialized service providers

A FePt-based biomimetic nanocapsule FP/Vad@CC-aT2 modified with triggering receptor 2 (TREM2) expressed on myeloid cells for delivering the STING agonist Vadimezan (Vad), where anti-TREM2 can effectively repolarize TAMs into M1 macrophages thereby reversing the immunosuppressive TME together with the Vad-activated STING pathway and inhibiting tumor recurrence (69)

Mandal PK, Tripathi M, Sugunan S