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The basis of the pathological change is the cells inability to prevent protein misfolding, to revert misfolded proteins to normal, or to eliminate misfolded proteins by degradation

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In preclinical studies, telaglenastat (CB-839), a Gln synthetase inhibitor, promoted the function of CD4 + Th 1 cells and CD8 + T cells, and inhibited the function of Th 17 cells
