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To test the hypothesis Mardinoglu, M., et
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Under quiescent conditions, cytosolic Nrf2 directly binds to Kelch-like ECH-associated protein 1 (Keap1), a substrate adapter protein for the Cul3E3ligase complex, resulting in rapid degradation of Nrf2 (Ulasov et al., 2022)
In addition, glucose6phosphate dehydrogenase (G6PDH) is a housekeeping enzyme that takes part in the pentose phosphate pathway and catalyzes the conversion of NADP + into NADPH, which is crucial for reducing oxidative stress within cells [69, 70]
