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Multidrug resistance (MDR) refers to the cross-tolerance of tumor cells to multiple chemotherapy drugs that are structurally and functionally unrelated (Cao et al., 2019), with the sensitivity of a tumor to different drugs decreasing or even disappearing after repeated exposure to one drug
Lipoic acid has insulin-mimetic activity [11], in that it improves glucose handling/utilization [4]
Multiple post-translational modification sites of G6PD were identified by mass spectrometry
Some people reasonably prefer to stick with approved therapies regardless of emerging research on alternatives
