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The mitochondrial inner membrane nicotinamide nucleotide transhydrogenase (NNT) also produces NADPH and this serves to couple reductive stress-induced H 2 O 2 production to NNT-associated NADPH and glutathione redox mechanisms [17]

On the other hand, non-enzymatic processes related to increased oxidative stress (OS) lead to the excessive accumulation of MDA, which has a high capacity to react with multiple biomolecules such as proteins and DNA [8]

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