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Bazedoxifene plus non-bioidentical conjugated estrogens and another SERM, ospemifene (Osphena), are used to treat genitourinary syndrome of menopause

doi: 10.1016/j.cytogfr.2022.06.003 263 NouriAMPanayiGS

It is hypothesized that following trauma, extracellular glutamate rises, initiating activation of N-methyl-D-aspartate (NMDA) receptors which promotes the influx of intracellular calcium ions (40)

From an environmental point of view, this is important because long-term exposures to MeHg in experimental studies better represent the chronic exposure in humans, who are normally exposed to the neurotoxicant for months or years