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Thus, glutaredoxin makes a significant contribution to the antioxidant protection of cells against the destructive effects of oxidative stress (Figure 2), which causes the formation of intra- and intermolecular disulfide bonds in proteins, the oxidation of functional SH-groups with the formation of sulfonic acid and the subsequent proteosomal degradation of the protein (Ren et al., 2017)

Evaluation of the safety, efficacy, and mechanism of action of obexelimab for the treatment of patients with IgG4-related disease: an open-label, single-arm, single centre, phase 2 pilot trial

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Fluorescent staining was visualized and images were acquired with a 63x oil immersion objective (NA = 1.2) with a 2x optical zoom on a Leica Stellaris 5 White Light Laser Confocal Microscope coupled to a camera integrated with LasX software for Lightning deconvolution (Leica Biosystems, Deer Park, IL, USA)