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Both complexes generated DNA strand breaks given byat least partiallythe oxidation of pyrimidine bases, which caused the arrest of the cell cycle in the G2/M phase

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A 2026 Nature Aging study found that adults with GSH:GSSG ratios below 10:1 had 2.8 times higher all-cause mortality risk compared to those above 20:1, independent of telomere length or other aging biomarkers
If the defense system cannot effectively remove these toxic products, it can result in an irreversible point of no return in the progression of ferroptosis
