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Abnormally increased interaction of FUS/TLS with SMN might affect its normal nuclear and/or cytoplasmic dynamics and lead to Gem body reduction and dysregulation of snRNA levels, a potential common mechanism of SMN deficiency in SMA

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Tiermodell: Nach Riss von Achillessehne, Patellasehne oder Rotatorenmanschette: deutliche Verkrzung der Heilungszeit in Tiermodellen sowie bessere biomechanische Werte (Zugfestigkeit, Elastizitt) ohne die Knochenablagerungen, die bei BMPs auftreten knnen

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