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Moreover, rats treated with 1% neohesperidin dihydrochalcone for 1 month showed reduced amygdala neuroinflammation via suppression of cAMP/PKA pathway activity, restoration of cortical 5-HT, DA, and NE levels, and reversal of anxiety- and depression-like behaviors (Jiang et al., 2023)

Additionally, social support plays a critical role in overcoming these barriers (Dionigi, 2007)
Always use a new, sterile syringe to decrease contamination

This timing can lead to sleep disruption, as symptoms are often most severe at bedtime
